Kathrin Wehlisch studied at Hochschule für Musik und Theater Mendelssohn Bartholdy in Leipzig. She was a member of the acting company of Theater Basel between 2000 and 2005, where she worked with directors Stefan Bachmann, Barbara Frey, Sebastian Nübling and Nicolas Stemann. During her tenure at Deutsches Theater Berlin from 2005 to 2009, she worked closely with Jürgen Gosch. From 2009, she had regular guest engagements at Deutsches Theater Berlin, Volksbühne am Rosa-Luxemburg-Platz and with Karin Beier at Schauspiel Köln. In 2013, Karin Beier invited her to join the company of Deutsches Schauspielhaus Hamburg. From 2016, Kathrin Wehlisch once again worked as a freelance actor at theatres like Deutsches Theater Berlin, SchauSpielHaus Hamburg and Teatro Arriaga Antzokia in Bilbao. She joined Berliner Ensemble in 2017/18.