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Three women, three generations: Carol – who appears to be living the perfect family life – commits suicide when her daughter Anna is 16 years old. Anna, who goes on to live in a commune and becomes addicted to drugs, takes her own life shortly after the birth of her daughter Bonnie. Bonnie tries to free herself from this fatal family pattern. She becomes a doctor and opposes her heritable depression and the looming danger of committing suicide with radical self-determination. Multiple award-winning author Alice Birch has composed a delicate score: The lives of the three women are narrated simultaneously, like a fugue, because their biographies are intertwined with each other across the generations and the longing for an autonomous life runs through them like a common thread.